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Ubiquitin Chains: Degradation and Beyond

Arnab De

978-3-319-14965-3

2015
Edition 1
- Nominated as an outstanding Ph.D. thesis by Columbia University, New York, USA
- Insightful and in-depth evaluation of the evidence for K63-linked regulatory ubiquitination in regulating cell-signalling in vitro
- First theses to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo
- Reports the generation of a knock-in mouse that expresses a mutated form of A20 selectively lacking the deubiquitinase activity
- Critically determines the role of the deubiquitinase function of A20 in limiting inflammatory responses in vivo
€180 €162
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