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The Cancer Degradome

Proteases and Cancer Biology

Dylan Edwards; Gunilla Hoyer-Hansen; Francesco Blasi; B.F. Sloane

978-0-387-69057-5

2008
Edition 1
- In the context of the battle against cancer, the Degradome is important in three principal areas:
- Cellular proteases and their inhibitors are components of the molecular machinery of malignancy, and thus are attractive as therapeutic targets. Importantly, we now appreciate that some proteases perform functions that antagonize tumour growth, and these are then anti-targets that must be avoided
- Degradome genes are valuable as prognostic and diagnostic markers of disease that can improve the accuracy of conventional clinical and histopathological assessment
- Cellular proteases are target molecules for improving tumour detection and imaging
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